3/15/2023
New Tests
NeoGenomics is excited to
announce the launch of both Neo Comprehensive – Solid Tumor and the upgraded
NeoTYPE® DNA & RNA – lung assays; a simpler, better, faster
approach to genomic profiling for solid tumors.
Product
Highlights
- Simpler: Both assays are NGS based
(DNA and RNA) with a NEW, simpler-to-interpret report.
- Better:
- Neo Comprehensive – Solid
Tumor: Comprehensive Genomic Profile with enhanced clinical coverage and
actionability from across 517 pan-cancer genes.
- NeoTYPE® DNA
& RNA – Lung: Targeted profile focusing in on 50 lung-specific genes.
- Both assays provide
enhanced detection of:
- SNVs, CNVs, InDels,
fusions, and splice variants
- MSI and TMB
- Superior RNA fusion
detection
- Reduced input
requirements.
- Faster: Results in 10-days*
*Specimens must be shipped
directly to NeoGenomics San Diego site for 10-day TAT. Please contact Client
Services number 866.776.5907, option 3 for a shipping label that goes directly
to San Diego.
**If medically necessary, PD-L1 can be added and will report separately.
IDH1/IDH2
Mutation Analysis by PCR is now
available for New York State orders!
- Methodology: the test is
performed by real-time PCR for optimal sensitivity. IDH1 and IDH2 will be
analyzed concurrently for detection of mutations at IDH1 codons R132X and
R100Q and at IDH2 codons R140X and R172X.
- Turnaround time (TAT): 5
days
- CPT Codes*: 81120, 81121
(MolDx CPT Code: 81479)
Flow Cytometry
B-ALL
MRD Flow Panel: Effective as of March 13th,
this panel is now orderable as either Bone Marrow or Peripheral Blood.
- B-ALL MRD Flow Panel (Bone
Marrow) will have additional antibodies to address the issue of
hemodilution of bone marrow aspirates, which limits flow cytometric
evaluation. The added antibodies will aid in evaluating the extent of
hemodilution in bone marrow specimens.
- Panel consists of two
tubes:
- Tube #1: same antibodies
as the current panel
- Tube #2 for additional
antibodies: CD16, CD14, CD13, CD45, and HLA-DR
- CPT Codes* have changed to:
88184x1, 88185x13 (88188x1 for global)
- B-ALL MRD Flow Panel
(Peripheral Blood)
- Panel of one tube will have
the same antibodies as the current panel.
- CPT Codes* remain the same:
88184x1, 88185x10 (88188x1 for global)
Flow User’s Guide has been
updated and is now available for download from NeoLINK under Documentation.
IHC
HER2 Breast IHC
Reporting - Effective as of March 13th,
HER2 Breast IHC Reporting has been updated to include both CAP/ASCO
guidelines and HER2 Low recommendations. As CAP/ASCO has not yet issued
recommendations on HER2 Low results associated with the therapy Enhertu®, this
update will allow our clients to report results and guide therapy decisions in
a way that best supports patient care.
Reference ranges, scoring results and graphs that are displayed in the results
section have been updated as shown below:
NOTE: Results reported that are considered either Equivocal/Low* or
Negative/Low* will have an auto-populating comment appear on the report with
information and references associated with HER2 Low.
Requisition Updates
The latest versions of the
requisition forms for Heme services are now available, as listed below. They
are available for download from the Neo website.
- Hematopathology Requisition
– version 030323
- Oncology Office Hematology
Requisition – version 021423
- New York Hematopathology
Requisition – version 021523
- New York Oncology Office
Hematology Requisition – version 022223
Please contact Client Services to
order paper copies. In the meantime,
- Download/print out these
updated requisitions and use them to order, or
- Write in orders from recent
test updates on existing requisitions. See previous NeoNEWS for info on
recent test updates.
*The CPT codes provided with our
test descriptions are based on AMA guidelines and are for informational
purposes only. Correct CPT coding is the sole responsibility of the billing
party. Please direct any questions regarding coding to the payor being billed.
Test Discontinuations
Molecular
Thyroid
Cancer Testing Program- Effective Saturday,
April 1, The Lilly Oncology Sponsored Thyroid Cancer Testing
Program (Thyroid STP), offering molecular testing at no cost to thyroid cancer
patients, will be discontinued.
- Orders received and
accessioned between now and March 31 will process through the Thyroid STP
as normal.
- Orders received and
accessioned on April 1 and beyond, will be put on hold while our Client
Services team reaches out to inform on alternative testing options.
Lung
Cancer Testing Program- Effective Sunday, April
16, The Lilly Oncology Sponsored Lung Cancer Testing Program (Lung
STP), offering molecular testing at no cost to non-small cell lung cancer (NSCLC)
patients, will be discontinued.
- Orders received and
accessioned between now and April 15 will process through the Lung STP as
normal.
- Orders received and
accessioned on April 16 and beyond, will be put on hold while our Client
Services team reaches out to inform on alternative testing options. Note:
NeoTYPE® DNA & RNA – Lung is the recommended alternative,
as this was the test performed as part of the program.
For any questions on the
discontinuation of these programs or for more information on alternative
suggestions, please contact your local NeoGenomics Sales Consultant or our
Client Services team at (866) 776-5907, option 3.
Additional Announcement
Online Orders 1.0 and
2.0
Required
Documents Upload/Acknowledgement - To support
obtaining complete information associated with an order, effective as of March
13th, 2023, a new acknowledgement prompt for uploading/sending documents has
been added to Online Orders 1.0 and 2.0. Clients placing an order will now need
to either upload required documents using the document uploader feature or
indicate, via a checkbox, that the required documents will be sent along with
the specimen. Documents required for submitting an order are:
- Face sheet
- Front/back of card for both
primary and secondary insurance
- Medical records:
Documentation support Medical Necessity of Test Performed (Office/Progress
Notes, recent CBC, Path Reports, H&P [History & Physical], etc.)
For Online Orders 1.0 users, the
prompt is located at the end of the order screen (see example below from Online
Orders 1.0). For Online Orders 2.0 users, the prompt is located on the Billing
screen.

***IMPORTANT: NEW EFFECTIVE DATES***
For the complete list of interface-related test changes that occurred on Monday
March 13th, click here
for a downloadable document to view the impacted interface test codes.